2019-07-22 08:57:202025-05-13 22:53:27

The protein

Catalyzed reaction/ biological activity

synthesis of c-di-AMP from two molecules of ATP [Pubmed|23192352]

2 ATP --> c-di-AMP + 2 diphosphate (according to UniProt)

The protein

[SW|Domains]

contains a [SW|DAC domain] involved in the synthesis of c-di-AMP [Pubmed|21566650]

[SW|DAC domain] (aa 82-242) (according to UniProt)

The protein

Effectors of protein activity

the interaction with [[protein|CdaR]] controls the diadenylate cyclase activity of [[protein|CdaA]] [Pubmed|23192352]

the interaction with [[protein|CdaR]] inhibits the diadenylate cyclase activity of [[protein|CdaA]] (shown in S. aureus) [pubmed|30668586]

the interaction with [[protein|CdaR]] controls the diadenylate cyclase activity of [[protein|CdaA]] [Pubmed|23192352]

the interaction with [[protein|CdaR]] inhibits the diadenylate cyclase activity of [[protein|CdaA]] (shown in S. aureus) [pubmed|30668586]

the interaction with [[protein|GlmM]] inhibits the diadenylate cyclase activity of [[protein|CdaA]] under conditions of osmotic stress (shown in L. monocytogenes) [pubmed|32250026]

The protein

Structure

[PDB|4RV7] (the [SW|DAC domain] and C-terminal domain of CdaA from ''Listeria monocytogenes'' (aa 101 - 273), 65% identity) [Pubmed|25605729]

[PDB|6HVL] (the [SW|DAC domain] and C-terminal domain of CdaA from ''Listeria monocytogenes'' (aa 101 - 273) in complex with c-di-AMP, 65% identity) [Pubmed|31118276]

[PDB|6HUW]

[PDB|4RV7] (the [SW|DAC domain] and C-terminal domain of CdaA from ''Listeria monocytogenes'' (aa 101 - 273), 65% identity) [Pubmed|25605729]

[PDB|6HVL] (the [SW|DAC domain] and C-terminal domain of CdaA from ''Listeria monocytogenes'' (aa 101 - 273) in complex with c-di-AMP, 65% identity) [Pubmed|31118276]

References

Reviews

18714086, 25869574, 23812326, 30224435

18714086, 25869574, 23812326, 30224435, 32472931, 32603625

References

Original publications

12884008, 21566650, 23192352, 22211522, 25605729, 25616256, 26240071, 26527648, 26585449, 28420751, 30668586, 31118276

32250026, 12884008, 21566650, 23192352, 22211522, 25605729, 25616256, 26240071, 26527648, 26585449, 28420751, 30668586, 31118276, 32250026

labs

[SW|Jörg Stülke], University of Göttingen, Germany [http://genmibio.uni-goettingen.de Homepage]